Chapter 7 – Drugs in Histocompatibility and Immunogenetics

The main classes of drugs used in Histocompatibility and Immunogenetics are for cancer treatment, for transplantation and for the treatment of autoimmunity. Often the same types of drugs are involved in all three scenarios.


Cancer treatment drugs are the antineoplastic agents. In transplantation, drug use involves some or all of pre transplant conditioning, post transplant immunosuppression, GvHD prophylaxis and treatment and treatment of infection. Pre transplant conditioning in the solid organ setting involves immunosuppression but in the stem cell setting involves eradication of disease using antineoplastic drugs to allow the preparation of ‘space’ for the graft and to immunosuppress the patient to prevent rejection and host versus graft reaction in allogeneic transplants.


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